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The administration of acetaminophen and codeine phosphate tablets or other opioids may possibly obscure the prognosis or scientific training course in people with acute abdominal circumstances.

If a individual is suspected to be enduring OIH, diligently think about correctly lowering the dose of the current opioid analgesic or opioid rotation (safely and securely switching the affected individual to a different opioid moiety) [see Dosage and Administration; Warnings].

Information and facts: If you should visit a&E, do not drive. Question somebody to travel you or phone 999 and ask for an ambulance.

Risk of Misuse and Addiction. Misusing codeine can result in severe aspect effects like coma or death. Misuse indicates having a medicine in a way in addition to how it was prescribed.

The concomitant utilization of acetaminophen and codeine phosphate tablets with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may perhaps result in lower codeine amounts, better norcodeine degrees, and less metabolism through 2D6 with resultant decreased morphine degrees.

No nonclinical fertility studies are already conducted with codeine or The mix of codeine and acetaminophen.

Breastfeeding. Tend not to acquire codeine if you are breastfeeding. Codeine can move into breast milk. Notify your healthcare service provider If you're breastfeeding or decide to breastfeed.

There are no enough and properly-controlled reports in Expecting Women of all ages. Acetaminophen and codeine phosphate tablets needs to be utilised during pregnancy provided that the prospective reward justifies the opportunity hazard into the fetus.

Don't share codeine with other people, even if they've got exactly the same affliction when you. It might harm them.

Prolonged use may result in tolerance and dependence within the drugs. Using codeine consistently for many years is often practice forming, which might result in you to definitely sense restless and irritable if you halt the tablets. Your medical doctor will end your tablets little by little in order to avoid you owning withdrawal indicators.

e., multiple copies from the gene for cytochrome P450 isoenzyme 2D6 or substantial check here morphine concentrations). Youngsters with snooze apnea can be specially delicate to the respiratory depressant effects of codeine. Due to the hazard of existence-threatening respiratory despair and Dying:

Sulfite Sensitivity Acetaminophen and codeine phosphate tablets incorporate sodium metabisulfite, a sulfite which could trigger allergic-sort reactions like anaphylactic signs and symptoms and everyday living-threatening or considerably less serious asthmatic episodes in certain susceptible men and women.

Effects around the Gastrointestinal Tract and Other Easy Muscle Codeine triggers a discount in motility associated with an increase in easy muscle mass tone inside the antrum from the abdomen and duodenum. Digestion of food items in the little intestine is delayed and propulsive contractions are decreased.

Whilst really serious, existence-threatening, or fatal respiratory melancholy can manifest at any time through using acetaminophen and codeine phosphate tablets, the danger is best through the initiation of therapy or next check here a dosage boost.